Abstract

Pericytes facilitate vessel maturation and endothelial barrier functions closely related with the pathogenesis of organ damage from cardiovascular and cerebrovascular diseases such as hypertension. We used a computational-based strategy to first screen for differentially expressed genes and lncRNAs and characterized associations between lncRNAs of microvascular pericytes and hypertension. In total, 22 lncRNAs were upregulated and 46 were downregulated in the rats afflicted with spontaneous hypertension. Expression profiles for lncRNAs were significantly altered in the hypertension afflicted tissue samples and the transcripts have good potential for use as molecular targets to inhibit the progression of hypertension.

摘要

周细胞促进血管成熟和内皮屏障功能，与高血压等心脑血管疾病器官损伤的发病机制密切相关。我们使用基于计算的策略首先筛选差异表达的基因和 lncRNA，并表征微血管周细胞的 lncRNA 与高血压之间的关联。在患有自发性高血压的大鼠中，总共有 22 个 lncRNA 被上调，46 个被下调。在受高血压影响的组织样本中，lncRNA 的表达谱发生了显着变化，并且该转录物具有用作抑制高血压进展的分子靶标的良好潜力。