This study investigated the mediating role of depressive symptoms among 147 middle-aged and older adults with FM in the relationship between pain intensity and 4 objective measures of physical performance: Fullerton Advanced Balance scale (FAB), 6-Minute Walk Test (6MWT), 30-Second Chair Stand (30SCS), and 8-Foot Up and Go Test (8FUPGT). Asymptotic mediation analyses revealed that depressive symptoms fully mediated the relationship between pain intensity and FAB (95% CI [−0.40, −0.10]) and 8FUPGT (CI [0.02, 0.11]) and partially mediated the relationship to 6MWT (CI [−9.15, −2.20]) and 30SCS (CI [−0.29, −0.06]). Findings support the evaluation of co-morbid depression in FM.

本研究调查了 147 名患有 FM 的中老年人的抑郁症状在疼痛强度与 4 种身体表现客观测量之间的关系中的中介作用：富勒顿高级平衡量表 (FAB)、6 分钟步行测试 (6MWT)、 30 秒椅架 (30SCS) 和 8 英尺起跑测试 (8FUPGT)。渐近中介分析显示，抑郁症状完全介导了疼痛强度与 FAB (95% CI [-0.40, -0.10]) 和 8FUPGT (CI [0.02, 0.11]) 之间的关系，并部分介导了与 6MWT 的关系 (CI [-9.15] , -2.20]) 和 30SCS (CI [-0.29, -0.06])。研究结果支持对 FM 合并抑郁症的评估。