Environmental exposure of humans to pollutants has been associated with adverse health outcomes, but few studies have evaluated the multiple exposure of general populations. In the present study, we used hair analysis to assess the exposure of a general adult population (n = 497) in Luxembourg to 34 persistent and 33 non-persistent organic pollutants from 11 chemical families, such as polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), organochlorine pesticides (OCPs), organophosphate pesticides (OPPs), and pyrethroid pesticides (PYRs). We detected 24 persistent and 29 non-persistent organic pollutants, with 17 pollutants being detected in more than 50% of hair samples. The median concentrations for pollutants detected in 100% of the samples were 0.37 pg/mg for lindane (γ-HCH), 0.15 pg/mg for hexachlorobenzene (HCB), 14.1 pg/mg for p-nitrophenyl (PNP), and 0.10 pg/mg for trifluralin. Each participant in this study had detectable levels of at least 10 of the pollutants analyzed, and 50% of participants had 19 or more, suggesting the simultaneous exposure to numerous different pollutants among our study population. Significant correlations were often found between pollutants from the same family, with the strongest being found between two PYR metabolites, trans/cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-carboxylic acid (Cl₂CA) and 3-phenoxybenzoic acid (3-PBA). Results from multiple linear regression analyses showed that sex, age and/or body mass index were significantly associated with 15 out of the 17 frequently detected pollutants. The current study is the first nationwide biomonitoring investigating organic contaminants in the Luxembourg population using hair analysis.

人类在环境中接触污染物与不良健康后果有关，但是很少有研究评估普通人群的多重接触。在本研究中，我们使用头发分析来评估卢森堡的一般成年人群（n = 497）暴露于来自11个化学家族的34种持久性和33种非持久性有机污染物，例如多氯联苯（PCB），多溴联苯醚（PBDEs），有机氯农药（OCP），有机磷酸盐农药（OPP）和拟除虫菊酯农药（PYR）。我们检测了24种持久性和29种非持久性有机污染物，其中超过50％的头发样本中检测到17种污染物。在100％的样品中检测到的污染物的中位浓度对于林丹（γ-HCH）为0.37 pg / mg，对于六氯苯（HCB）为0.15 pg / mg。对硝基苯基（PNP）为1 pg / mg，三氟拉林为0.10 pg / mg。这项研究的每位参与者均具有至少10种可检测到的污染物可检测水平，而50％的参与者具有19种或更多，这表明我们的研究人群中同时暴露于多种不同的污染物。通常在同一家族的污染物之间发现显着的相关性，其中最强的是两种PYR代谢物，反式/顺式-3-（2,2-二氯乙烯基）-2,2-二甲基环丙烷-羧酸（Cl ₂ CA）和3-苯氧基苯甲酸（3-PBA）。多重线性回归分析的结果表明，性别，年龄和/或体重指数与17种经常检测到的污染物中的15种显着相关。当前的研究是第一个使用毛发分析技术对卢森堡人口中的有机污染物进行全国性的生物监测。