The effects of the concomitant infection by COVID-19 and Burkholderia cepacia (Bc) in CF are not known. We describe the case of a 34 years woman with CF, colonized by Bc and found SARS-CoV2 positive. In the first hospital week she suffered acute respiratory failure and chest imaging showed interstitial involvement and multiple thickenings. She was treated with antibiotics, dexamethasone, remdesivir and heparin, with gradual improvement and discharge at day 20th. The reciprocal role of SARS-CoV-2 and Bc, their potential interactions and the contribution of the individual therapies to the favourable outcome are unclear. It is debatable whether it was SARS-CoV2 that triggered a Bc pulmonary exacerbation or if the chronic Bc infection facilitated the development of a COVID-19 more aggressive than usually seen in CF. If the latter hypothesis were confirmed by similar cases, Bc colonization should be regarded as a risk factor for severe COVID-19 expression in CF.

COVID-19 和洋葱伯克霍尔德菌 (Bc) 合并感染对 CF 的影响尚不清楚。我们描述了一名患有 CF 的 34 岁女性的病例，她被 Bc 定植并发现 SARS-CoV2 呈阳性。在住院的第一周，她出现了急性呼吸衰竭，胸部成像显示间质受累和多处增厚。她接受了抗生素、地塞米松、瑞德西韦和肝素治疗，病情逐渐好转并于第 20 天出院。SARS-CoV-2 和 Bc 的相互作用、它们的潜在相互作用以及个体疗法对有利结果的贡献尚不清楚。是否是 SARS-CoV2 引发了 Bc 肺部恶化，或者慢性 Bc 感染是否促进了 COVID-19 的发展，这比通常在 CF 中看到的更具侵略性，这还有待商榷。