Rheumatoid arthritis (RA), which mainly results from fibroblast-like synoviocyte (FLS) dysfunction, is related to oxidative stress. Advanced oxidation protein products (AOPPs), which are proinflammatory mediators and a novel biomarker of oxidative stress, have been observed to accumulate significantly in the serum of RA patients. Here, we present the first investigation of the effects of AOPPs on RA-FLSs and the signalling pathway involved in AOPP-induced inflammatory responses and invasive behaviour.

中文翻译：

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先进的氧化蛋白产物通过RAGE-NF-κB途径诱导成纤维样滑膜细胞的炎症反应和侵袭行为。

类风湿关节炎（RA）主要由成纤维样滑膜细胞（FLS）功能障碍引起，与氧化应激有关。已观察到高级氧化蛋白产物（AOPPs）是促炎性介质和氧化应激的新生物标记，在RA患者的血清中大量积聚。在这里，我们目前对AOPP对RA-FLSs的影响以及涉及AOPP诱导的炎症反应和侵袭性行为的信号传导途径进行了首次调查。