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Advanced oxidation protein products induce inflammatory responses and invasive behaviour in fibroblast-like synoviocytes via the RAGE-NF-κB pathway.
Bone & Joint Research ( IF 4.7 ) Pub Date : 2021-4-9 , DOI: 10.1302/2046-3758.104.bjr-2020-0085.r2
Aiju Lou 1, 2 , Le Wang 3, 4 , Weinan Lai 1 , DingJi Zhu 1 , Weirong Wu 2 , Zhao Wang 3, 4 , Zihong Cai 3, 4 , Min Yang 1
Affiliation  

Rheumatoid arthritis (RA), which mainly results from fibroblast-like synoviocyte (FLS) dysfunction, is related to oxidative stress. Advanced oxidation protein products (AOPPs), which are proinflammatory mediators and a novel biomarker of oxidative stress, have been observed to accumulate significantly in the serum of RA patients. Here, we present the first investigation of the effects of AOPPs on RA-FLSs and the signalling pathway involved in AOPP-induced inflammatory responses and invasive behaviour.

中文翻译:

先进的氧化蛋白产物通过RAGE-NF-κB途径诱导成纤维样滑膜细胞的炎症反应和侵袭行为。

类风湿关节炎(RA)主要由成纤维样滑膜细胞(FLS)功能障碍引起,与氧化应激有关。已观察到高级氧化蛋白产物(AOPPs)是促炎性介质和氧化应激的新生物标记,在RA患者的血清中大量积聚。在这里,我们目前对AOPP对RA-FLSs的影响以及涉及AOPP诱导的炎症反应和侵袭性行为的信号传导途径进行了首次调查。
更新日期:2021-04-11
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