The rational design of drug delivery systems has aroused significant concern toward improving therapeutics in recent years. Material innovation has promoted more reasonable strategies for the drug encapsulation and delivery. Among the various nanocarriers, the crystalline porous framework material metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) have been developed as an attractive kind of upstarts owing to their predefined structure and function by virtue of the charm of reticular chemistry. Moreover, compared with other amorphous materials, their precise framework structures and defined pores by molecular-level control can improve the efficacy of drug administration, and provide novel strategies for precision of targeting delivery. In this mini review, we summarize and illustrate the most recent progress of MOF- or COF-based carriers for drug delivery, focusing on their structure design, function regulation, and fascinating application. Furthermore, we also discuss the major challenges and future development prospects in this field.

近年来，药物输送系统的合理设计引起了人们对改善治疗方法的极大关注。物质创新促进了更合理的药物封装和递送策略。在各种纳米载体中，凭借网状化学的魅力，由于其预定的结构和功能，结晶多孔骨架材料金属-有机骨架（MOF）和共价有机骨架（COF）已被开发为有吸引力的新贵。此外，与其他无定形材料相比，它们的精确框架结构和通过分子水平控制确定的孔可以提高药物给药的效率，并为靶向递送的精确度提供新的策略。在这个迷你评论中，我们总结并说明了基于MOF或COF的载体在药物输送中的最新进展，重点是它们的结构设计，功能调节和引人入胜的应用。此外，我们还将讨论该领域的主要挑战和未来发展前景。