In the study of acute myeloid leukemia (AML), TLS-ERG (also called FUS-ERG or TLS/FUS-ERG) was found to be closely associated with extramedullary disease (EMD), with very poor prognosis. However, the occurrence of TLS-ERG in acute lymphoblastic leukemia (ALL) is very rare. Till date, only 20 cases of ALL with TLS-ERG gene have been reported, of which six are children. Therefore, many clinical aspects of ALL with TLS-ERG gene remain unknown. The aim of this study was to report the clinical features and outcomes of four TLS-ERG-positive pediatric ALL cases. The results showed that all four pediatric patients with this fusion gene achieved an excellent outcome even with a very short-term induction chemotherapy of less than two months. These findings indicated that children with TLS-ERG-positive ALL have very low risk of leukemia, and can be treated and cured with less intensive chemotherapy.

在急性髓系白血病（AML）的研究中，发现TLS-ERG（也称为FUS-ERG或TLS/FUS-ERG）与髓外疾病（EMD）密切相关，预后极差。然而，TLS-ERG 在急性淋巴细胞白血病 (ALL) 中的发生非常罕见。迄今为止，仅报告了 20 例具有 TLS-ERG 基因的 ALL 病例，其中 6 例为儿童。因此，具有 TLS-ERG 基因的 ALL 的许多临床方面仍然未知。本研究的目的是报告四例 TLS-ERG 阳性儿科 ALL 病例的临床特征和结果。结果表明，即使进行了不到两个月的非常短期的诱导化疗，所有四名具有这种融合基因的儿科患者都取得了很好的结果。这些发现表明 TLS-ERG 阳性 ALL 的儿童患白血病的风险非常低，