Voluntary rapid eye movements (saccades) redirect the fovea toward objects of visual interest. The saccadic system can be considered as a dual-mode system: in one mode the eye is fixating, in the other it is making a saccade. In this review, we consider two examples of dysfunctional saccades, interrupted saccades in late-onset Tay-Sachs disease and gaze-position dependent opsoclonus after concussion, which fail to properly shift between fixation and saccade modes. Insights and benefits gained from bi-directional collaborative exchange between clinical and basic scientists are emphasized. In the case of interrupted saccades, existing mathematical models were sufficiently detailed to provide support for the cause of interrupted saccades. In the case of gaze-position dependent opsoclonus, existing models could not explain the behavior, but further development provided a reasonable hypothesis for the mechanism underlying the behavior. Collaboration between clinical and basic science is a rich source of progress for developing biologically plausible models and understanding neurological disease. Approaching a clinical problem with a specific hypothesis (model) in mind often prompts new experimental tests and provides insights into basic mechanisms.

自愿快速眼球运动（扫视）将中央凹重定向到视觉感兴趣的对象。扫视系统可以被认为是一个双模式系统：在一种模式下，眼睛是注视的，另一种是进行扫视。在这篇综述中，我们考虑了两个功能障碍性扫视的例子，迟发性 Tay-Sachs 病中的中断扫视和脑震荡后凝视位置依赖的眼阵挛，它们无法在注视和扫视模式之间正确转换。强调了从临床科学家和基础科学家之间的双向协作交流中获得的见解和好处。在眼跳中断的情况下，现有的数学模型足够详细，可以为眼跳中断的原因提供支持。在凝视位置依赖opsoclonus的情况下，现有模型无法解释行为，但进一步的发展为行为背后的机制提供了合理的假设。临床和基础科学之间的合作是开发生物学上合理的模型和理解神经疾病的丰富进展来源。考虑到特定假设（模型）来处理临床问题通常会提示新的实验测试并提供对基本机制的见解。