ABSTRACT

Introduction

Magnetoliposomes have gained increasing attention as delivery systems, as they surpass many limitations associated with liposomes. The combination with magnetic nanoparticles provides a means for development of multimodal and multifunctional theranostic agents that enable on-demand drug release and real-time monitoring of therapy.

Areas covered

Recently, several magnetoliposome structures have been reported to ensure efficient transport and delivery of therapeutics, while improving magnetic properties. Besides, novel techniques have been introduced to improve on-demand release, as well as to achieve sequential release of different therapeutic agents. This review presents the major types and methods of preparation of magnetoliposomes, and discusses recent strategies in the trigger of drug release, development of theranostic formulations, and delivery of drugs and biological entities.

Expert opinion

Despite significant advances in efficient drug delivery, current literature lacks an assessment of formulations as theranostic agents and complementary techniques to optimize thermotherapy efficiency. Plasmonic magnetoliposomes are highly promising multimodal and multifunctional systems, providing the required design versatility to optimize theranostic capabilities. Further, photodynamic therapy and delivery of proteins/genes can be improved with a deeper research on the employed magnetic material and associated toxicity. A scale-up procedure is also lacking in recent research, which is limiting their translation to clinical use.

中文翻译：

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磁脂质体：受控给药领域的最新进展

摘要

介绍

磁脂质体作为递送系统越来越受到关注，因为它们超越了与脂质体相关的许多限制。与磁性纳米粒子的结合为开发多模式和多功能治疗诊断剂提供了一种手段，使按需药物释放和实时监测治疗成为可能。

覆盖区域

最近，已经报道了几种磁脂质体结构，以确保有效运输和递送治疗剂，同时改善磁性。此外，还引入了新技术来改善按需释放，以及实现不同治疗剂的顺序释放。本综述介绍了制备磁脂质体的主要类型和方法，并讨论了在触发药物释放、治疗诊断制剂的开发以及药物和生物实体的递送方面的最新策略。

专家意见

尽管在有效药物输送方面取得了重大进展，但目前的文献缺乏对作为治疗诊断剂的制剂和优化热疗效率的补充技术的评估。等离子磁脂质体是非常有前途的多模式和多功能系统，提供所需的设计多功能性以优化治疗诊断能力。此外，通过对所用磁性材料和相关毒性的更深入研究，可以改进光动力疗法和蛋白质/基因的传递。最近的研究也缺乏扩大规模的程序，这限制了它们在临床应用中的转化。