Nanostructures generated by self-assembly of peptides yield nanomaterials that have many therapeutic applications, including drug delivery and biomedical engineering, due to their low cytotoxicity and higher uptake by targeted cells owing to their high affinity and specificity towards cell surface receptors. Despite the promising implications of this rapidly expanding field, there is no dedicated resource to study peptide nanostructures. This study endeavours to create a repository of short peptides, which may prove to be the best models to study ordered nanostructures formed by peptide self-assembly. SAPdb has a repertoire of 1049 entries of experimentally validated nanostructures formed by the self-assembly of small peptides. It consists of 328 tripeptides, 701 dipeptides, and 20 single amino acids with some conjugate partners. Each entry encompasses comprehensive information about the peptide, such as chemical modifications, the type of nanostructure formed, experimental conditions like pH, temperature, solvent required for the self-assembly, etc. Our analysis indicates that peptides containing aromatic amino acids favour the formation of self-assembling nanostructures. Additionally, we observed that these peptides form different nanostructures under different experimental conditions. SAPdb provides this comprehensive information in a hassle-free tabulated manner at a glance. User-friendly browsing, searching, and analysis modules have been integrated for easy data retrieval, data comparison, and examination of properties. We anticipate SAPdb to be a valuable repository for researchers engaged in the burgeoning arena of nanobiotechnology. It is freely available at https://webs.iiitd.edu.in/raghava/sapdb.

通过肽的自组装产生的纳米结构由于其低细胞毒性和归因于其对细胞表面受体的高亲和力和特异性而被靶向细胞吸收，从而产生了具有许多治疗应用的纳米材料，包括药物递送和生物医学工程。尽管这个快速扩展的领域带来了令人鼓舞的影响，但没有专门的资源来研究肽纳米结构。这项研究致力于创建一个短肽库，这可能是研究由肽自组装形成的有序纳米结构的最佳模型。SAPdb具有1049个通过小肽的自组装形成的经过实验验证的纳米结构的库。它由328个三肽，701个二肽和20个具有一些共轭伴侣的单氨基酸组成。每个条目都包含有关该肽的全面信息，例如化学修饰，形成的纳米结构的类型，实验条件（如pH值，温度，自组装所需的溶剂等）。我们的分析表明，含芳香族氨基酸的肽有利于形成肽。自组装纳米结构。另外，我们观察到这些肽在不同的实验条件下形成不同的纳米结构。SAPdb一目了然地以列表形式轻松提供了这些全面的信息。集成了用户友好的浏览，搜索和分析模块，可轻松进行数据检索，数据比较和属性检查。我们预计SAPdb将成为从事纳米生物技术新兴领域研究人员的宝贵资料库。