Abstract

Objective

Pathogenesis of Behçet disease (BD) has not yet been clearly revealed and there is no ideal test for the estimation of disease activation at present. This study aimed to assess the efficiencies of IgG/IgM and IgA/C3 ratios in determining activation of BD.

Method

This retrospective cohort study consisted of 140 patients with BD. Patients were divided into two groups: (1) active BD (n = 89) and (2) inactive BD (n = 51) and were compared in terms of demographic features, clinical characteristics and laboratory test results. IgA/C3 and IgG/IgM ratios were compared according to organ system involvement; receiver operating characteristic (ROC) curve analysis was performed in order to assess the performance of IgA/C3 and IgG/IgM ratios in determining patient disease status.

Results

Significantly higher levels of erythrocyte sedimentation rate, C-reactive protein, IgA, G, C4, IgA/C3, IgG/IgM ratios (p = .007 for IgA and p < .001 for others) and significantly lower levels of IgM and C3 were observed in patients with active BD (p < .001). The IgG/IgM ratio was significantly higher in patients with vascular involvement (p = .017) and the IgA/C3 ratio was significantly higher in patients with arthritis (p = .007). Cut-off values of 0.019 (70.8% sensitivity, 62% specificity) and 7.08 (84.3% sensitivity, 80% specificity) were determined for IgA/C3 and IgG/IgM ratios, respectively.

Conclusion

IgA/C3 and IgG/IgM ratios may be used as additional parameters for the assessment of BD status.

中文翻译：

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免疫球蛋白 A/补体 3 和免疫球蛋白 G/免疫球蛋白 M 比值在评估白塞病患者疾病激活中的效用

摘要

客观的

白塞病 (BD) 的发病机制尚未明确揭示，目前还没有理想的方法来估计疾病的激活程度。本研究旨在评估 IgG/IgM 和 IgA/C3 比率在确定 BD 激活方面的效率。

方法

这项回顾性队列研究包括 140 名 BD 患者。患者分为两组：（1）活动性BD（n  = 89）和（2）非活动性BD（n  = 51），并在人口统计学特征、临床特征和实验室检查结果方面进行比较。根据器官系统受累情况比较 IgA/C3 和 IgG/IgM 比率；进行受试者工作特征 (ROC) 曲线分析以评估 IgA/C3 和 IgG/IgM 比率在确定患者疾病状态方面的表现。

结果

红细胞沉降率、C 反应蛋白、IgA、G、C4、IgA/C3、IgG/IgM 比值（ IgA p = .007  ，其他p < .001）显着升高，而 IgM 和 C3 显着降低在活动性 BD 患者中观察到 ( p  < .001)。血管受累患者的 IgG/IgM 比值显着更高 ( p  = .017)，关节炎患者的 IgA/C3 比值显着更高 ( p  = .007)。IgA/C3 和 IgG/IgM 比率的临界值分别为 0.019（70.8% 敏感性，62% 特异性）和 7.08（84.3% 敏感性，80% 特异性）。

结论

IgA/C3 和 IgG/IgM 比率可用作评估 BD 状态的附加参数。