Global bacterial infections associated with conventional polyvinyl chloride (PVC) medical devices place a heavy burden on healthcare systems and thus it will be desirable if medical devices are made from antimicrobial PVC. There are numerous studies focusing on polymer surface modifications to either leach antimicrobial agents or kill pathogenic microbes upon direct contact. In this work, mannitol fumarate ester-based aluminum metal alkoxide (MFE-Al) additive was developed to confer simultaneously improved antibacterial property and enhanced high temperature sterilization resistance of the resultant PVC. Data obtained confirm that the MFE-Al stabilized PVC sheets significantly inhibit 98% bacterial growth. They also show biocompatibility with cultured H9C2 cardiomyocytes and hemocompatibility in vitro. Dry heat sterilization is generally not suitable for PVC medical wares due to their poor thermal compatibility. Surprisingly, our antimicrobial-biocompatible PVC can maintain stability at 180°C for 90 min. Such a high thermal stability indicates the MFE-Al stabilized PVC can endure 90 cycles of dry-heat sterilization without significant damage. This study may provide a solution to reduce PVC medical waste for a maximum benefit without compromising human health or the environment.

中文翻译：

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通过添加烷氧基铝改善聚氯乙烯的抗菌、生物相容性和可重复使用性能

与传统聚氯乙烯 (PVC) 医疗器械相关的全球细菌感染给医疗保健系统带来了沉重负担，因此医疗器械由抗菌 PVC 制成将是可取的。有许多研究侧重于聚合物表面改性，以通过直接接触来浸出抗菌剂或杀死病原微生物。在这项工作中，开发了基于甘露醇富马酸酯的铝金属醇盐 (MFE-Al) 添加剂，以同时提高所得 PVC 的抗菌性能和增强的耐高温灭菌性。获得的数据证实，MFE-Al 稳定的 PVC 片材可显着抑制 98% 的细菌生长。它们还显示出与培养的 H9C2 心肌细胞的生物相容性和体外血液相容性。PVC医疗器具热相容性差，一般不适合干热灭菌。令人惊讶的是，我们的抗菌生物相容性 PVC 可以在 180°C 下保持稳定性 90 分钟。如此高的热稳定性表明 MFE-Al 稳定的 PVC 可以承受 90 次干热灭菌循环而没有明显损坏。这项研究可能会提供一种解决方案，在不损害人类健康或环境的情况下，减少 PVC 医疗废物以获得最大利益。