Michael Reth has made many landmark contributions to immunology during his career, including the discovery of the two signaling subunits (CD79a/b) of the B cell antigen receptor (BCR) and the immunoreceptor tyrosine-based activation motif. More recently, he has worked on elucidating the nanoscale organization of the plasma membrane of B cells and studying the B cell–specific membrane protein CD20, which is a target of therapeutic antibodies against B cell tumors and B cell–associated autoimmune diseases. Now a professor of molecular immunology at the University of Freiburg in Germany, Reth was elected to the National Academy of Sciences in 2018 as an International Member. In his Inaugural Article, Reth describes his findings on the role of CD20 as a gatekeeper of a receptor nanocluster on resting mature human B cells (1).

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QnAs 与 Michael Reth

Michael Reth 在他的职业生涯中为免疫学做出了许多具有里程碑意义的贡献，包括发现了 B 细胞抗原受体 (BCR) 的两个信号亚基 (CD79a/b) 和基于免疫受体酪氨酸的激活基序。最近，他致力于阐明 B 细胞质膜的纳米级组织，并研究 B 细胞特异性膜蛋白 CD20，这是针对 B 细胞肿瘤和 B 细胞相关自身免疫疾病的治疗性抗体的靶标。Now a professor of molecular immunology at the University of Freiburg in Germany, Reth was elected to the National Academy of Sciences in 2018 as an International Member. 在他的首篇文章中，Reth 描述了他关于 CD20 作为受体纳米团簇的守门人的作用的发现（1））。