Aims

This pilot study aimed to determine if increased serum ferritin (SF) is associated with cardiovascular risk factors in patients with prediabetes.

Methods

Eighteen patients with prediabetes and 36 subjects without prediabetes (control), non-white Hispanic, non-indigenous origin, Mexican mestizo descent were included. Participants had no inflammation, or vascular complications. SF and metabolic markers were evaluated in both groups.

Results

SF and oxidized low-density lipoprotein (oxLDL) were increased in prediabetes subjects. Moreover, in prediabetes and control groups as a whole, natural logarithm (ln)-SF correlated with oxLDL and ln-oxLDL/LDL after adjustment for sex, ln-age, ln-fasting plasma glucose (FPG), ln-body mass index, ln-triglyceride (TG), total cholesterol (TC), and high-density lipoproteins. Finally, ln-SF was an independent contributor to ln-oxLDL/LDL ratio in control and prediabetes subjects (β = 0.2915) after the introduction of potential confounders such as FPG, TC, TG, and hypertension.

Conclusions

The results of this study indicate that hyperferritinemia is associated with oxLDL, considered one of the main cardiovascular risk factors, which allows us to suggest that an increase in SF could contribute to the progression of prediabetes, prior to the appearance of diabetes. Further research is required to establish a causal relationship of iron disruption metabolism in oxLDL generation under prediabetes conditions.

中文翻译：

---

增加的血清铁蛋白与糖尿病前期患者的氧化低密度脂蛋白有关：一项初步研究

目标

这项初步研究旨在确定血清铁蛋白 (SF) 升高是否与糖尿病前期患者的心血管危险因素相关。

方法

包括 18 名患有前驱糖尿病的患者和 36 名没有前驱糖尿病（对照）、非白人西班牙裔、非土著血统、墨西哥混血血统的受试者。参与者没有炎症或血管并发症。对两组的 SF 和代谢标志物进行了评估。

结果

SF 和氧化低密度脂蛋白 (oxLDL) 在糖尿病前期受试者中增加。此外，在糖尿病前期和对照组中，在对性别、ln-年龄、ln-空腹血糖 (FPG)、ln-体重指数进行调整后，自然对数 (ln)-SF 与 oxLDL 和 ln-oxLDL/LDL 相关、ln-甘油三酯 (TG)、总胆固醇 (TC) 和高密度脂蛋白。最后，在引入 FPG、TC、TG 和高血压等潜在混杂因素后，ln-SF 是对照组和糖尿病前期受试者 (β = 0.2915) 的 ln-oxLDL/LDL 比率的独立贡献者。

结论

这项研究的结果表明，高铁蛋白血症与 oxLDL 相关，oxLDL 被认为是主要的心血管危险因素之一，这使我们能够提出，在糖尿病出现之前，SF 的增加可能有助于糖尿病前期的进展。需要进一步的研究来确定在前驱糖尿病条件下铁破坏代谢在 oxLDL 生成中的因果关系。