Enzymatic electrochemical continuous flow cascade synthesis of substituted benzimidazoles,Reaction Chemistry & Engineering

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Enzymatic electrochemical continuous flow cascade synthesis of substituted benzimidazoles
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2021-3-18 , DOI: 10.1039/d1re00058f
Ting-Ting Shi _{1,

2,

3,

4,

5} , Shu-Zhan Wang _{1,

2,

3,

4} , Zhao Yang _{6,

7,

8,

9} , Yilin Wang _{1,

2,

3,

4} , Chengkou Liu _{1,

2,

3,

4} , Wei He _{1,

2,

3,

4} , Zheng Fang _{1,

2,

3,

4,

10} , Kai Guo _{1,

2,

3,

4,

10}

Affiliation

A green and efficient method for the synthesis of substituted benzimidazoles has been developed in a two-step continuous flow system. Enzymatic electrochemical cascade reactions between aromatic alcohols and o-phenylenediamines are reported. The reaction was performed under mild reaction conditions with air as the “green” oxidant and oxidase as the biocatalyst. Alcohol oxidation and substituted benzimidazole formation, which are usually accomplished separately, were integrated into a single operation. A scale up experiment was completed successfully in a continuous flow system which offers an industrially relevant, practical and efficient method.

中文翻译：

酶促电化学连续流动级联合成取代苯并咪唑

在两步连续流系统中，开发了一种绿色高效的合成取代苯并咪唑的方法。据报道芳族醇和邻苯二胺之间的酶促电化学级联反应。反应在温和的反应条件下进行，空气为“绿色”氧化剂，氧化酶为生物催化剂。通常分别完成的醇氧化和取代的苯并咪唑的形成被整合到一个操作中。在连续流系统中成功完成了放大实验，该系统提供了与工业相关，实用且有效的方法。

更新日期：2021-04-09

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