In this letter, we established the feasibility of producing localized ablation zones using microsecond pulsed microwave ablation (MWA) as an alternative to conventional continuous wave (CW) MWA. We verified that a thin floating-sleeve dipole ablation probe can withstand pulsed power delivery with peak powers as high as 25 kW, with pulsewidth on the order of 1 μs. We conducted MWA experiments in egg white using CW and pulsed modes of operation and found that ablation zones achieved via pulsed MWA are comparable in dimension to those created via CW MWA when the average power and procedure duration are equivalent. Finally, we performed pulsed MWA experiments in bovine liver and confirmed that pulsed MWA consistently produces large, localized ablation zones and temperatures that exceed 100 °C. Establishing the feasibility of pulsed MWA opens the opportunity for developing a coupled MWA treatment and imaging system using pulsed MWA and microwave-induced thermoacoustic signals for real-time monitoring of MWA.

中文翻译：

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使用微创天线微秒脉冲微波消融的可行性研究

在这封信中，我们确立了使用微秒脉冲微波消融（MWA）替代常规连续波（CW）MWA来生产局部消融区的可行性。我们验证了一个薄的浮套偶极消融探头可以承受峰值功率高达25 kW，脉冲宽度约为1μs的脉冲功率传输。我们使用CW和脉冲操作模式在蛋清中进行了MWA实验，发现当平均功率和过程持续时间相同时，通过脉冲MWA实现的消融区域在尺寸上与通过CW MWA创建的消融区域相当。最后，我们在牛肝中进行了脉冲MWA实验，并确认脉冲MWA始终产生较大的局部消融区，并且温度超过100°C。