Journal of Cardiovascular Translational Research ( IF 2.4 ) Pub Date : 2021-04-08 , DOI: 10.1007/s12265-021-10123-x Ke Li 1 , Leonardo Wagner 1 , Angel Moctezuma-Ramirez 1 , Deborah Vela 2 , Emerson Perin 3
|
In this study, we created a reproducible myocardial infarction (MI) model in pigs characterized by a low mortality rate and significant changes in left ventricular function. After administering an arrhythmia prevention regimen, we created a 90-min balloon-induced percutaneous MI in 42 pigs below the first diagonal branch (D1) of the left anterior descending artery. Echocardiograms were performed before and 14 days after MI induction. Pigs with a > 30% decrease in left ventricular ejection fraction (LVEF) underwent electrophysiological mapping by the NOGA system. Our mortality rate was 4.8%. The incidence of ventricular fibrillation (VF) was 28.6%; all VF events were successfully resuscitated. At day 14, echocardiography and NOGA mapping confirmed transmural scar. LVEF decreased 41% from baseline. Radial and circumferential strain significantly decreased in the LAD distal to D1, and the LV showed dyssynchrony. An anti-arrhythmia regimen decreased mortality significantly, and our model induced dramatic functional changes.
Graphical abstract
中文翻译：
猪经皮心肌梗死模型及其对左心室功能的影响
在这项研究中，我们在猪中创建了一个可重复的心肌梗塞 (MI) 模型，其特点是死亡率低且左心室功能发生显着变化。在实施心律失常预防方案后，我们在左前降支第一对角支 (D1) 以下的 42 头猪中创建了 90 分钟球囊诱导的经皮 MI。在 MI 诱导前和 14 天后进行超声心动图检查。左心室射血分数 (LVEF) 降低 > 30% 的猪接受了 NOGA 系统的电生理绘图。我们的死亡率为 4.8%。心室颤动（VF）的发生率为28.6%；所有 VF 事件均成功复苏。在第 14 天，超声心动图和 NOGA 映射证实了透壁瘢痕。LVEF 较基线下降 41%。D1 远端 LAD 的径向和周向应变显着降低，LV 显示不同步。抗心律失常方案显着降低了死亡率，并且我们的模型引起了显着的功能变化。
京公网安备 11010802027423号