Abstract

Introduction

Three Words-Three Shapes (3W3S) is a bedside test that assesses verbal and non-verbal memory and has proven useful in staging memory decline in amnestic disorders and primary progressive aphasia. Given its simple structure, the 3W3S can be easily adapted to other languages maintaining the original shapes and only modifying the words. We aim to validate a Spanish version of the 3W3S test and establish whether memory loss patterns present in amnesic disorders associated with Alzheimer's etiology and PPA were correctly characterized.

Method

The translation and adaptation of the 3W3S were performed according to standardized guidelines and applied to a cohort of patients with Dementia of Alzheimer's type (DAT = 20), mild cognitive impairment (aMCI= 20), primary progressive aphasia (PPA = 20), and healthy controls (HC = 20).

Results

In verbal memory performance, PPA patients' score was lower than that of MCI and HC and similar to DAT's in the effortless encoding (p < 0.001), delayed recall (p < 0.001), and recognition (p < 0.012). For non-verbal performance, PPA patients performed better than DAT and similar to HC and MCI subjects (p < 0.001).

Conclusions

Results show good applicability of 3W3S to determine memory function in PPA patients, independently from language ability. Visual and verbal components of memory are dissociated in PPA.

中文翻译：

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西班牙语版本的三个单词-三个形状测试用于检测原发性进行性失语症的记忆障碍的效用

摘要

介绍

三字三形 (3W3S) 是一项床边测试，可评估语言和非语言记忆，并已证明可用于记忆遗忘症和原发性进行性失语症的分期记忆衰退。鉴于其简单的结构，3W3S 可以很容易地适应其他语言，保持原来的形状，只修改单词。我们旨在验证西班牙语版本的 3W3S 测试，并确定与阿尔茨海默病病因学和 PPA 相关的健忘症中存在的记忆丧失模式是否得到正确表征。

方法

3W3S 的翻译和改编是根据标准化指南进行的，并应用于一组患有阿尔茨海默病型痴呆 (DAT = 20)、轻度认知障碍 (aMCI= 20)、原发性进行性失语症 (PPA = 20) 和健康对照 (HC = 20)。

结果

在语言记忆表现方面，PPA 患者的得分低于 MCI 和 HC，但在轻松编码 ( p  < 0.001)、延迟回忆 ( p  < 0.001) 和识别 ( p  < 0.012) 方面与 DAT 相似。对于非语言表现，PPA 患者的表现优于 DAT，与 HC 和 MCI 受试者相似（p  < 0.001）。

结论

结果表明 3W3S 在确定 PPA 患者的记忆功能方面具有良好的适用性，与语言能力无关。记忆的视觉和语言成分在 PPA 中分离。