Aim

Albuminuria and left ventricular hypertrophy are important predictors of cardiovascular disease. We speculated that albuminuria increases the risk of left ventricular hypertrophy in patients with type 2 diabetes and early renal impairment.

Methods

A total of 330 patients with type 2 diabetes and early renal insufficiency were recruited and classified according to albuminuria level (normal albuminuria, microalbuminuria, and macroalbuminuria). Plasma glucose, glycated hemoglobin (HbA1c), creatinine, uric acid, fasting insulin, albuminuria/urine creatinine ratio, renal function, insulin sensitivity, visceral fat index, body mass index, blood pressure, and left ventricular mass were assessed. The relationship between albuminuria and left ventricular hypertrophy was examined using logistic regression analysis and multiple linear regression.

Results

The risk of left ventricular hypertrophy was higher in the microalbuminuria group (odds ratio [OR] 14.602, 95% confidence interval [CI] 7.050–30.243) and macroalbuminuria group (OR 21.455, 95% CI 8.613–53.443) than in the normal albuminuria group.

Conclusions

Albuminuria increases the risk of left ventricular hypertrophy in patients with type 2 diabetes and early renal insufficiency.

中文翻译：

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蛋白尿增加早期肾功能不全的2型糖尿病患者左室肥大的风险

目的

蛋白尿和左心室肥大是心血管疾病的重要预测指标。我们推测白蛋白尿会增加2型糖尿病和早期肾功能不全患者左室肥大的风险。

方法

总共招募了330名2型糖尿病和早期肾功能不全的患者，并根据蛋白尿水平（正常蛋白尿，微量白蛋白尿和大量白蛋白尿）进行分类。评估血浆葡萄糖，糖化血红蛋白（HbA1c），肌酐，尿酸，空腹胰岛素，蛋白尿/尿肌酐比率，肾功能，胰岛素敏感性，内脏脂肪指数，体重指数，血压和左心室重量。使用logistic回归分析和多元线性回归分析白蛋白尿与左心室肥大之间的关系。

结果

微量白蛋白尿组（比值比[OR] 14.602，95％置信区间[CI] 7.050–30.243）和巨蛋白尿症组（OR 21.455，95％CI 8.613–53.443）的左室肥大风险高于正常白蛋白尿。团体。

结论

蛋白尿会增加2型糖尿病和早期肾功能不全患者左室肥大的风险。