Prior to COVID-19, only two human-tropic coronaviruses resulted in epidemics and cerebrovascular disease was rarely reported. Evidence now suggests that 1–6% of hospitalized COVID-19 patients develop stroke. According to some reports, stroke risk is more than sevenfold greater in patients with COVID-19 than influenza. Concerningly, outcomes of COVID-19-related stroke are often worse than in stroke patients without COVID-19 from the same cohorts. In this review, we highlight the emerging association between COVID-19 and stroke and discuss putative pathogenetic mechanisms. Etiology of stroke in COVID-19 patients is likely multifactorial, related to coagulopathy, inflammation, platelet activation, and alterations to the vascular endothelium. Significant work remains to be done to better understand the pathogenesis of COVID-19-related stroke and for designing optimal primary and secondary prevention strategies.

在COVID-19之前，只有两种嗜人冠状病毒导致流行，脑血管病的报道很少。现在有证据表明，1-6% 的住院 COVID-19 患者会发生中风。根据一些报告，COVID-19 患者的中风风险是流感患者的七倍多。令人担忧的是，与 COVID-19 相关的中风患者的结局通常比来自同一队列的没有 COVID-19 的中风患者更差。在这篇综述中，我们强调了 COVID-19 与中风之间新出现的关联，并讨论了推定的发病机制。COVID-19 患者中风的病因可能是多因素的，与凝血病、炎症、血小板活化和血管内皮细胞的改变有关。