We propose a mechanism underlying polyglutamine (polyQ) repeat expansion diseases, in which the translation of expanded CAG codon repeats leads to translation stress. The stress is generated by depletion of the cognate glutaminyl-tRNA pool, which could cause ribosome frameshifting and lead to mistranslation of transcripts with specific characteristics. Michele Vendruscolo and colleagues propose that polyglutamine repeat expansion diseases could be caused by glutaminyl-tRNA depletion, leading to ribosome frameshifting and mistranslation of transcripts with specific characteristics.

中文翻译：

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多聚谷氨酰胺扩张疾病的易错译转录组

我们提出了一种潜在的多聚谷氨酰胺 (polyQ) 重复扩增疾病的机制，其中扩增的 CAG 密码子重复的翻译导致翻译压力。压力是由同源谷氨酰胺酰-tRNA 池的耗尽产生的，这可能导致核糖体移码并导致具有特定特征的转录物的错误翻译。Michele Vendruscolo 及其同事提出，多聚谷氨酰胺重复扩增疾病可能由谷氨酰胺酰-tRNA 耗竭引起，导致核糖体移码和具有特定特征的转录本的错误翻译。