The anti-inflammatory effects of a 50% aqueous extract of Rosa roxburghii fruit (RRFE) and two ellagitannins (strictinin and casuarictin) isolated from the RRFE were evaluated in a cell model of skin inflammation induced by self-RNA released from epidermal cells damaged by UV ray (UVR) irradiation. The RRFE inhibited interleukin-8 (IL-8) mRNA expression in normal human epidermal keratinocytes (NHEKs) stimulated with polyinosinic:polycytidylic acid (poly(I:C)), a ligand of toll-like receptor-3 (TLR-3). The plant-derived anti-inflammatory agents, dipotassium glycyrrhizinate (GK2) and allantoin, had no influence on the IL-8 expression. The purified compounds, strictinin and casuarictin, inhibited the IL-8 mRNA expression and IL-8 release induced in NHEKs by poly(I:C). These ellagitannins were thus found to be responsible for the biological activity exhibited by the RRFE. This study demonstrates that RRFE and isolated RRFE compounds show promise as ingredients for products formulated to improve skin disorders induced by UVR irradiation.

50％罗莎果提取物的抗炎作用在由RRFE分离的表皮细胞释放的自身RNA诱导的皮肤炎症细胞模型中，对从RRFE中分离出的水果（RRFE）和两种鞣花单宁（strictinin和casuarictin）进行了评估。RRFE抑制了多肌苷酸：聚胞苷酸（poly（I：C））（一种收费蛋白样受体3（TLR-3）的配体）刺激的正常人表皮角质形成细胞（NHEK）中的白细胞介素8（IL-8）mRNA表达。 。植物来源的抗炎药甘草酸双钾（GK2）和尿囊素对IL-8表达没有影响。纯化的化合物，丁氨丁草素和木麻黄素，抑制了聚（I：C）在NHEKs中诱导的IL-8 mRNA表达和IL-8释放。因此，发现这些鞣花单宁与RRFE表现出的生物活性有关。