The heavy metal lead (Pb) is a contaminant widely distributed in the food chain. In this study, eight weeks of feeding containing Garlic (Allium sativum) or Fu-ling (Poria cocos) or both, markedly increased the growth index, enzyme activity, and serum index and significantly decreased muscle Pb level in grass carp (Ctenopharyngodon idella). Upon Pb exposure, the feeding Garlic or Fu-ling or both possessed the similar effects on improving the function of the antioxidant system and chelating ability. Further, the gene expressions of metal binding proteins (TF and MT-2) in the liver of the three experimental groups were significantly higher than those of the control group, which were all highly up-regulated after Pb exposure. At the same time, the activities of antioxidant enzymes (SOD and CAT) and the content of non-enzymatic substance (GSH) in the liver of the Garlic group, Fu-ling group and mixed group were stable compared to the control group after Pb exposure. Moreover, the reduction of Pb toxicity was manifested by the decrease of Pb content in the muscle, and the stable expression of heat stress proteins (HSP30 and HSP60) and immune-related genes (TNF-α and IL-1β). Taken together, the study preliminarily shows that the Garlic and Fu-ling play a role in mitigating the toxicity of Pb in grass carp.

重金属铅（Pb）是在食物链中广泛分布的污染物。在这项研究中，喂食大蒜（大蒜）或Fu陵（Por）或两者同时喂食的八周，显着提高了草鱼（Ctenopharyngodon idella）的生长指数，酶活性和血清指数，并显着降低了肌肉铅水平。。暴露于Pb时，大蒜或福凌或两者饲喂对改善抗氧化系统的功能和螯合能力具有相似的作用。此外，金属结合蛋白（TF和MT-23个实验组肝脏中的）均显着高于对照组，后者在Pb暴露后均显着上调。同时，大蒜组，Fu陵组和混合组肝脏中抗氧化酶（SOD和CAT）的活性以及非酶类物质（GSH）的含量与对照组相比，Pb后较稳定。接触。此外，Pb毒性的降低表现为肌肉中Pb含量的减少以及热应激蛋白（HSP30和HSP60）和免疫相关基因（TNF-α和IL-1β）的稳定表达。）。综上所述，该研究初步表明，大蒜和Fu陵在减轻草鱼中铅的毒性方面发挥了作用。