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FermFooDb: A database of bioactive peptides derived from fermented foods
Heliyon ( IF 3.4 ) Pub Date : 2021-04-08 , DOI: 10.1016/j.heliyon.2021.e06668
Anita Chaudhary 1 , Sherry Bhalla 2 , Sumeet Patiyal 2 , Gajendra P S Raghava 2 , Girish Sahni 3
Affiliation  

Globally fermented foods are in demands due to their functional and nutritional benefits. These foods are sources of probiotic organisms and bioactive peptides, various amino acids, enzymes etc. that provides numerous health benefits. FermFooDb (https://webs.iiitd.edu.in/raghava/fermfoodb/) is a manually curated database of bioactive peptides derived from wide range of foods that maintain comprehensive information about peptides and process of fermentation. This database comprises of 2205 entries with following major fields, peptide sequence, Mass and IC50, food source, functional activity, fermentation conditions, starter culture, testing conditions of sequences in vitro or in vivo, type of model and method of analysis. The bioactive peptides in our database have wide range of therapeutic potentials that includes antihypertensive, ACE-inhibitory, antioxidant, antimicrobial, immunomodulatory and cholesterol lowering peptides. These bioactive peptides were derived from different types of fermented foods that include milk, cheese, yogurt, wheat and rice. Numerous, web-based tools have been integrated to retrieve data, peptide mapping of proteins, similarity search and multiple-sequence alignment. This database will be useful for the food industry and researchers to explore full therapeutic potential of fermented foods from specific cultures.



中文翻译:


FermFooDb:发酵食品中生物活性肽的数据库



全球发酵食品因其功能和营养价值而受到欢迎。这些食物是益生菌和生物活性肽、各种氨基酸、酶等的来源,可提供多种健康益处。 FermFooDb (https://webs.iiitd.edu.in/raghava/fermfoodb/) 是一个手动管理的生物活性肽数据库,该数据库源自多种食品,保留有关肽和发酵过程的全面信息。该数据库包含2205条条目,主要领域包括肽序列、质量和IC50、食物来源、功能活性、发酵条件、发酵剂、体外体内序列测试条件、模型类型和分析方法。我们数据库中的生物活性肽具有广泛的治疗潜力,包括抗高血压、ACE 抑制、抗氧化、抗菌、免疫调节和降低胆固醇肽。这些生物活性肽源自不同类型的发酵食品,包括牛奶、奶酪、酸奶、小麦和大米。许多基于网络的工具已被集成以检索数据、蛋白质肽图、相似性搜索和多序列比对。该数据库将有助于食品行业和研究人员探索特定培养物发酵食品的全部治疗潜力。

更新日期:2021-04-08
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