The objective of the present article was to qualitatively and quantitatively review the association between chronic mechanical irritation and oral squamous cell carcinoma (OSCC). PubMed, SCOPUS, and Web of Science databases were searched using the keyword combinations "chronic trauma and oral squamous cell carcinoma; chronic irritation and oral squamous cell carcinoma; chronic irritation and oral cancer; and chronic trauma and oral cancer." Duplicates and irrelevant articles were excluded after the title and abstract screening. The full texts of the remaining articles were assessed using selection criteria. A total of 375 (PubMed-126; SCOPUS-152; WOS-97) articles were screened, and 343 duplicates and irrelevant articles were excluded from the study. Only 9 of the remaining 32 articles met the selection criteria and were included in the qualitative analysis. Buccal mucosa and tongue, being highly prone to chronic irritation through the dental prosthesis, were the common sites for OSCC. Edentulous subjects with ill-fitting dentures were at a high risk of developing chronic irritation associated-OSCC. According to the Joanna Briggs Institute of risk assessment, eight of the nine included studies had a low risk of bias. The quantitative analysis showed a significant association (p < 0.00001) between the chronic oral mucosal irritation and OSCC with an overall risk ratio of 2.56 at a confidence interval of 1.96-3.35. Chronic oral mucosa irritation has a significant association with OSCC, and the nature of association could be that of a potential co-factor (dependent risk factor) rather than an independent risk factor.

中文翻译：

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慢性机械刺激和口腔鳞状细胞癌：系统评价和荟萃分析。

本文的目的是定性和定量地评价慢性机械刺激与口腔鳞状细胞癌 (OSCC) 之间的关系。使用关键字组合“慢性创伤和口腔鳞状细胞癌；慢性刺激和口腔鳞状细胞癌；慢性刺激和口腔癌；以及慢性创伤和口腔癌”搜索 PubMed、SCOPUS 和 Web of Science 数据库。标题和摘要筛选后排除重复和不相关的文章。其余文章的全文使用选择标准进行评估。共筛选出 375 篇（PubMed-126；SCOPUS-152；WOS-97）文章，排除了 343 篇重复和不相关的文章。其余 32 篇文章中只有 9 篇符合选择标准并被纳入定性分析。口腔黏膜和舌头极易受到假牙的慢性刺激，是 OSCC 的常见部位。具有不合适假牙的无牙颌受试者患慢性刺激相关性 OSCC 的风险很高。根据乔安娜布里格斯风险评估研究所的数据，九项纳入研究中有八项偏倚风险较低。定量分析显示慢性口腔黏膜刺激与 OSCC 之间存在显着关联（p < 0.00001），总体风险比为 2.56，置信区间为 1.96-3.35。慢性口腔黏膜刺激与 OSCC 显着相关，