Introduction: The goal of this study was to histopathologically evaluate the appearance of degrading MIRAgel scleral buckles so that they can be reliably distinguished by ophthalmic pathologists from other foreign materials. Methods: Retrospective chart review and histopathologic study with special stains, including Alcian blue, periodic acid-Schiff, Masson’s trichrome, and Perls’ Prussian blue for iron, of 4 cases between 2017 and 2019. Results: Hydrolyzed MIRAgel scleral buckles from 4 patients had a consistent histopathologic appearance. They had a honeycomb structure with the walls of the lattice ranging from distinct to poorly defined. The walls of the lattice were positive for Alcian blue, while the contents of each cell contained periodic acid-Schiff-positive material. Other special stains were not as valuable in highlighting the material. Discussion: Although the capsules of MIRAgel scleral buckles have been well studied, the material itself has not been. While clinical history and radiographic appearance are often diagnostic of a hydrolyzed MIRAgel scleral buckle, there are instances of preoperative ambiguity where histopathologic confirmation can be useful. Conclusions: MIRAgel scleral buckles have a distinct histopathologic appearance that can be readily distinguished from that of other foreign materials.
Ocul Oncol Pathol

中文翻译：

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水解 MIRAgel 巩膜扣带的组织病理学

简介：本研究的目的是组织病理学评估降解 MIRAgel 巩膜扣的外观，以便眼科病理学家能够可靠地将它们与其他异物区分开来。方法：对 2017 年至 2019 年 4 例病例进行回顾性图表回顾和组织病理学研究，采用特殊染色剂，包括阿新蓝、高碘酸-希夫、马松三色和 Perls 普鲁士蓝进行铁染色。结果：来自 4 名患者的水解 MIRAgel 巩膜扣具有一致的组织病理学外观。它们具有蜂窝结构，格子的壁从明显到不明确。晶格壁对阿尔新蓝呈阳性，而每个细胞的内容物含有高碘酸-希夫阳性物质。其他特殊污渍在突出材料方面没有那么有价值。讨论：虽然 MIRAgel 巩膜扣带的胶囊已经得到很好的研究，但材料本身还没有。虽然临床病史和影像学表现通常可以诊断水解 MIRAgel 巩膜扣带，但在一些术前不确定的情况下，组织病理学确认可能是有用的。结论：MIRAgel 巩膜扣带具有明显的组织病理学外观，可以很容易地与其他异物区分开来。
眼肿瘤病理