The common reason for mortality globally is myocardial infarction. The study aimed to evaluate Passiflora edulis (PE) fruit juice potential in the experimental isoproterenol (ISO) treated rat model to manage myocardial injury. ISO (20 mg/100 g body weight) treated rats showed a significant increment in serum marker enzymes lactate dehydrogenase (LDH) and creatinine kinase (CK), serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), serum alkaline phosphatase (ALP) and serum acid phosphatase (ACP) activity. Besides, phosphorus and calcium, serum cholesterol, and triglyceride levels (TG) were high in ISO groups. A significant decline in antioxidant activity and histopathological alteration was observed in ISO treated groups. PE juice pre-treatment (2 ml/kg) for 28 days and ISO treatment on the 29th and 30th days showed a protective effect on distorted biochemical and histopathologic parameters compared with reference drug metoprolol. These findings indicate the cardioprotective effect of PE juice on ISO-induced myocardial infracted rats.

全球范围内导致死亡的常见原因是心肌梗塞。该研究旨在评估西番莲（PE）在经异丙肾上腺素（ISO）处理的大鼠模型中可能具有治疗心肌损伤的潜在果汁。经ISO（20 mg / 100 g体重）处理的大鼠的血清标志物酶乳酸脱氢酶（LDH）和肌酐激酶（CK），血清谷氨酸丙酮酸转氨酶（SGPT），血清谷氨酸草酰乙酸转氨酶（SGOT）显着增加磷酸酶（ALP）和血清酸性磷酸酶（ACP）的活性。此外，ISO组中的磷和钙，血清胆固醇和甘油三酸酯（TG）含量较高。在ISO治疗组中观察到抗氧化剂活性和组织病理学改变显着下降。与参考药物美托洛尔相比，PE汁预处理（2 ml / kg）进行28天，ISO处理在第29天和第30天显示出对扭曲的生化和组织病理学参数的保护作用。这些发现表明PE汁对ISO诱导的心肌梗塞大鼠的心脏保护作用。