The vessels of the central nervous system (CNS) have unique barrier properties. The endothelial cells (ECs) which comprise the CNS vessels contribute to the barrier via strong tight junctions, specific transporters, and limited endocytosis which combine to protect the brain from toxins and maintains brain homeostasis. Blood–brain barrier (BBB) leakage is a serious secondary injury in various CNS disorders like stroke, brain tumors, and neurodegenerative disorders. Currently, there are no drugs or therapeutics available to treat specifically BBB damage after a brain injury. Growing knowledge in the field of epigenetics can enhance the understanding of gene level of the BBB and has great potential for the development of novel therapeutic strategies or targets to repair a disrupted BBB. In this brief review, we summarize the epigenetic mechanisms or regulators that have a protective or disruptive role for components of BBB, along with the promising approaches to regain the integrity of BBB.

中文翻译：

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血脑屏障破坏中的表观遗传学

中枢神经系统 (CNS) 的血管具有独特的屏障特性。构成中枢神经系统血管的内皮细胞 (EC) 通过强大的紧密连接、特定的转运蛋白和有限的内吞作用来形成屏障，这些作用结合起来可以保护大脑免受毒素的侵害并维持大脑的稳态。血脑屏障（BBB）渗漏是中风、脑肿瘤和神经退行性疾病等各种中枢神经系统疾病的严重继发性损伤。目前，还没有药物或疗法可以专门治疗脑损伤后的 BBB 损伤。表观遗传学领域知识的不断增长可以增强对 BBB 基因水平的理解，并且对于开发修复受损 BBB 的新治疗策略或目标具有巨大潜力。在这篇简短的综述中，我们总结了对 BBB 成分具有保护或破坏作用的表观遗传机制或调节因子，以及恢复 BBB 完整性的有前景的方法。