ABSTRACT

Introduction

Proteomics, i.e. the study of the set of proteins produced in a cell, tissue, organism, or biological entity, has made possible analyses and contextual comparisons of proteomes/proteins and biological functions among the most disparate entities, from viruses to the human being. In this way, proteomic scrutiny of tumor-associated proteins, autoantigens, and pathogen antigens offers the tools for fighting cancer, autoimmunity, and infections.

Areas covered

Comparative proteomics and immunoproteomics, the new scientific disciplines generated by proteomics, are the main themes of the present review that describes how comparative analyses of pathogen and human proteomes led to re-modulate the molecular mimicry concept of the pre-proteomic era. I.e. before proteomics, molecular mimicry – the sharing of peptide sequences between two biological entities – was considered as intrinsically endowed with immunologic properties and was related to cross-reactivity. Proteomics allowed to redefine such an assumption using physicochemical parameters according to which frequency and hydrophobicity preferentially confer an immunologic potential to shared peptide sequences.

Expert opinion

Proteomics is outlining peptide platforms to be used for the diagnostics and management of human diseases. A Molecular Medicine targeted to obtain healing without paying the price for adverse events is on the horizon. The next step is to take up the challenge and operate the paradigm shift that the current proteomic era requires.

中文翻译：

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蛋白质组学在定义自身免疫中的作用

摘要

介绍

蛋白质组学，即对细胞、组织、有机体或生物实体中产生的一组蛋白质的研究，已经对从病毒到人类的最不同实体之间的蛋白质组/蛋白质和生物学功能进行了可能的分析和上下文比较。通过这种方式，对肿瘤相关蛋白、自身抗原和病原体抗原的蛋白质组学检查为对抗癌症、自身免疫和感染提供了工具。

涵盖的领域

比较蛋白质组学和免疫蛋白质组学是蛋白质组学产生的新科学学科，是本综述的主题，描述了病原体和人类蛋白质组的比较分析如何导致重新调节前蛋白质组时代的分子模拟概念。即在蛋白质组学之前，分子模拟——在两个生物实体之间共享肽序列——被认为具有内在的免疫特性，并且与交叉反应有关。蛋白质组学允许使用物理化学参数重新定义这种假设，根据频率和疏水性优先赋予共享肽序列免疫潜力。

专家意见

蛋白质组学正在概述用于人类疾病诊断和管理的肽平台。一种旨在在不为不良事件付出代价的情况下获得治愈的分子医学即将出现。下一步是迎接挑战并实施当前蛋白质组时代所需的范式转变。