Background

To assess the incidence of new-onset diabetes after transplantation (NODAT) for the first year post-transplantation and the predictive value of high-sensitivity C-reactive Protein (hs-CRP) before transplantation for NODAT prediction in kidney transplantation patients.

Material and methods

A study of 251 consecutive adult end-stage kidney disease patients transplanted kidneys from living donors, follow-up during the first year to find NODAT. We diagnosed NODAT based on blood glucose or HbA1c following to the criteria of the American Diabetes Association.

Results

The ratio of NODAT was 12.4%. The mean age, mean BMI, the proportion of arteriosclerosis, and the median hs-CRP level in NODAT group were significantly higher than those of non-NODAT group with p < 0.05. Age, BMI and serum hs-CRP had a predictive value for NODAT (Age: AUC = 0.62, p < 0.05, BMI: AUC = 0.626, hs-CRP: AUC = 0.748, p < 0.001).

Conclusion

Serum hs-CRP level measured prior transplantation is a good predictor for NODAT in renal transplant recipients.

中文翻译：

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血清 hs-CRP 测量的先前移植预测肾移植受者移植后新发糖尿病

背景

评估移植后第一年新发糖尿病（NODAT）的发生率以及移植前高敏C反应蛋白（hs-CRP）对肾移植患者NODAT预测的预测价值。

材料与方法

一项对 251 名连续成年终末期肾病患者进行的研究从活体捐献者身上移植了肾脏，并在第一年进行随访以发现 NODAT。我们根据美国糖尿病协会的标准，根据血糖或 HbA1c 诊断出 NODAT。

结果

NODAT的比率为12.4%。NODAT组平均年龄、平均BMI、动脉硬化比例和中位hs-CRP水平均显着高于非NODAT组，p  < 0.05。年龄、BMI 和血清 hs-CRP 对 NODAT 具有预测价值（年龄：AUC = 0.62，p < 0.05，BMI：AUC = 0.626，hs-CRP：AUC = 0.748，p  < 0.001）。

结论

移植前测量的血清 hs-CRP 水平是肾移植受者 NODAT 的良好预测指标。