A known monoterpene, named γ-terpineol, was incorporated in mixed Langmuir monolayers composed of dipalmitoyl-phosphoethanolamine (DPPE) and peptidoglycans as a model of microbial membranes. Surface pressure and surface potential isotherms, dynamical surface rheology, Brewster angle microscopy (BAM), and infrared spectroscopy were employed to characterize the compound-membrane interactions. The compound expanded the monolayers denoting repulsive interactions. At 30 mN/m, the monolayer presented lower viscoelastic and in-plane elasticity parameters and an increased all-trans/gauche conformers ratio for the alkyl chains, confirming molecular order. The morphology of the monolayer was analyzed by BAM, which revealed a heterogeneous distribution of γ-terpineol along the mixed monolayer, which tends to segregate. In conclusion, the compound changes the thermodynamic, electric, rheological, morphological, and structural properties of the peptidoglycan-DPPE monolayer, which may be essential to understand, at the molecular level, the action of bioactives in selected membrane models.

一种名为 γ-萜品醇的已知单萜被掺入由二棕榈酰磷酸乙醇胺 (DPPE) 和肽聚糖组成的混合朗缪尔单层膜中，作为微生物膜的模型。采用表面压力和表面电位等温线、动态表面流变学、布鲁斯特角显微镜 (BAM) 和红外光谱来表征复合膜相互作用。该化合物扩大了表示排斥相互作用的单层。在 30 mN/m 时，单层表现出较低的粘弹性和面内弹性参数，以及增加的烷基链的全反式/gauche 构象比，证实了分子顺序。通过 BAM 分析单层的形态，这表明 γ-萜品醇沿混合单层分布不均匀，倾向于分离。综上所述，