Cilostazol (CLZ) is a quinolinone derivative possessing anti platelet and vasodilating properties and it is used in the treatment of intermittent claudication. It operates by inhibiting the cyclic guanosine monophosphate (cGMP) dependent phosphodiesterase III which leads to availability of cyclic adenosine monophosphate (cAMP) in blood vessels and platelets owing to vasodilation and reduced calcium-induced contractions. This article illustrates the various reported quantitative methods which can be used to determine cilostazol and its metabolites either alone or in combination forms in pharmaceutical preparation or biological matrices like plasma, serum, and urine. The review covers analytical methods like ultraviolet spectroscopy, fluorescence spectroscopy, electrometric methods, nuclear magnetic resonance spectroscopy, high performance liquid chromatography, high performance thin layer chromatography, ultra-high performance liquid chromatography, and tandem mass spectroscopy from the year 1985 to 2019 with a brief explanation on every analytical method. Among the methods, it was found that most researchers opted for UV and HPLC analytical methods for the estimation of cilostazol.

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评估药物制剂和生物样品中西洛他唑的定量技术的分析综述

西洛他唑（CLZ）是一种具有抗血小板和血管舒张特性的喹啉酮衍生物，用于间歇性lau行治疗。它通过抑制环状鸟苷单磷酸（cGMP）依赖性磷酸二酯酶III来运作，由于血管舒张作用和减少的钙诱导的收缩，导致血管和血小板中环状腺苷单磷酸（cAMP）的可用性。本文介绍了各种已报道的定量方法，这些方法可用于确定西洛他唑及其代谢产物的单独或组合形式，用于确定药物制剂或生物基质（例如血浆，血清和尿液）中的西洛他唑及其代谢物。该评论涵盖了各种分析方法，例如紫外光谱，荧光光谱，静电测定，核磁共振光谱，1985年至2019年的高效液相色谱法，高性能薄层色谱法，超高效液相色谱法和串联质谱法，并对每种分析方法进行了简要说明。在这些方法中，发现大多数研究人员选择了UV和HPLC分析方法来评估西洛他唑。