Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification, and quantitation in the gas phase. In this study, enantiomeric molecules of ibuprofen and flurbiprofen were clearly recognized by forming host–guest complex ions using trapped ion mobility time-of-flight mass spectrometry. Ternary complex ions can be produced easily by electrospray ionization of the mixed solutions of ibuprofen, cyclodextrins, and CaCl₂, LiCl, or NaCl, as well as flurbiprofen, cyclodextrins, and CaCl₂. The relative contents of different chiral ibuprofens in a mixed solution were also quantitatively measured. This new method is a simple, effective, and a convenient enantioselective analysis method.

中文翻译：

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通过气相中与金属阳离子和环糊精的三元配合物的离子迁移质谱法直接区分布洛芬和氟比洛芬对映体

对映体药物应用广泛，在制药中发挥着重要作用。离子迁移谱与质谱技术相结合，提供了一种在气相中区分对映体药物、对映体鉴定和定量的独特方法。在这项研究中，通过使用捕获离子迁移率飞行时间质谱法形成主客体复合离子，可以清楚地识别布洛芬和氟比洛芬的对映体分子。通过对布洛芬、环糊精和 CaCl ₂、LiCl 或 NaCl 以及氟比洛芬、环糊精和 CaCl ₂的混合溶液进行电喷雾电离，可以很容易地产生三元复合离子. 还定量测量了混合溶液中不同手性布洛芬的相对含量。这种新方法是一种简单、有效、方便的对映选择性分析方法。