The application of green chemistry principles is foundational in the route section and route development for active pharmaceutical ingredients at Amgen. In this perspective we present several examples where the application of concepts like atom economy, solvent minimization, reagent optimization, synthetic convergence, reduced energy use, real-time analysis and strong safety focus have contributed to the development of processes that are significantly greener and more environmentally friendly that the corresponding starting points. The selected examples span different levels of molecular complexity, and many of the presented examples have been reduced to practice on significant scale.

中文翻译：

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绿色化学作为制药行业创新的驱动力

绿色化学原理的应用是安进活性药物成分路线部分和路线开发的基础。从这个角度来看，我们提供了几个例子，其中原子经济、溶剂最小化、试剂优化、合成收敛、减少能源使用、实时分析和强烈的安全重点等概念的应用有助于开发更绿色和更多的工艺。环保即相应的出发点。选定的示例跨越不同级别的分子复杂性，并且许多呈现的示例已被简化为大规模实践。