当前位置: X-MOL 学术Nature › 论文详情
Astrocytes close a motor circuit critical period
Nature ( IF 42.778 ) Pub Date : 2021-04-07 , DOI: 10.1038/s41586-021-03441-2
Sarah D. Ackerman, Nelson A. Perez-Catalan, Marc R. Freeman, Chris Q. Doe

Critical periods—brief intervals during which neural circuits can be modified by activity—are necessary for proper neural circuit assembly. Extended critical periods are associated with neurodevelopmental disorders; however, the mechanisms that ensure timely critical period closure remain poorly understood1,2. Here we define a critical period in a developing Drosophila motor circuit and identify astrocytes as essential for proper critical period termination. During the critical period, changes in activity regulate dendrite length, complexity and connectivity of motor neurons. Astrocytes invaded the neuropil just before critical period closure3, and astrocyte ablation prolonged the critical period. Finally, we used a genetic screen to identify astrocyte–motor neuron signalling pathways that close the critical period, including Neuroligin–Neurexin signalling. Reduced signalling destabilized dendritic microtubules, increased dendrite dynamicity and impaired locomotor behaviour, underscoring the importance of critical period closure. Previous work defined astroglia as regulators of plasticity at individual synapses4; we show here that astrocytes also regulate motor circuit critical period closure to ensure proper locomotor behaviour.



中文翻译:

星形胶质细胞关闭运动回路的关键时期

关键时期-可以通过活动修改神经回路的简短间隔-对于正确的神经回路组装是必需的。关键时期延长与神经发育障碍有关;然而,确保及时关闭关键时期的机制仍然知之甚少1,2。在这里,我们定义了发展中的果蝇运动回路中的关键时期,并确定星形胶质细胞对于适当的关键时期终止至关重要。在关键时期,活动的变化调节了运动神经元的树突长度,复杂性和连通性。在关键时期关闭之前,星形胶质细胞侵入了神经纤维3,星形胶质细胞消融延长了关键时期。最后,我们使用了遗传筛选来鉴定关闭关键时期的星形胶质细胞-运动神经元信号传导途径,包括Neuroligin-Neurexin信号传导。减少信号不稳定的树突状微管,增加树突动态性和运动行为受损,强调了关键时期关闭的重要性。以前的工作将星形胶质细胞定义为各个突触的可塑性调节剂4 ; 我们在这里表明,星形胶质细胞还调节运动回路的关键时期关闭,以确保适当的运动行为。

更新日期:2021-04-08
全部期刊列表>>
2021中国学者有奖调研
JACS
材料科学跨学科高质量前沿研究
中国作者高影响力研究精选
虚拟特刊
屿渡论文,编辑服务
何川
清华大学
郭维
上海中医药大学
华东师范大学
北京大学许言
楚甲祥
西湖石航
上海交大
北理工
隐藏1h前已浏览文章
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
南开大学
张韶光
华辉
天合科研
x-mol收录
试剂库存
down
wechat
bug