Chrysobalanus orbicularis is a medicinal plant present in West Africa in the Itsekiri speaking part of Nigeria. It is used conventionally in diabetes mellitus management. This research investigates the ameliorative activity of the aqueous leaf extract of C. orbicularis in a streptozotocin-induced diabetic rat model. Freshly prepared streptozotocin (40 mg/kg body weight [BW]) was administered intraperitoneally to induce diabetes. Three diabetic groups were placed on aqueous leaf extract of C. orbicularis at 11.076, 22.134, and 44.268 mg/kg BW respectively; a group was placed on metformin (44.28 mg/kg BW), and the other two groups were the diabetic control and normal control. The experiment lasted for 28 days, thereafter, fasting blood glucose levels and body weight variations were recorded. Also, glycogen level, antioxidant enzyme, hexokinase and glucose-6-phosphatase activities, malonaldehyde (MDA) as well as glucose transporters 2 and 4 levels were analyzed using standard procedures. Diabetic rats administered aqueous extract of C. orbicularis leaf significantly (p < 0.05) decreased the fasting blood glucose and MDA levels, and glucose-6-phosphatase activity. In addition, administration of aqueous extract of C. orbicularis leaf to diabetic rats demonstrated a momentous increase in liver glycogen level, superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, glutathione transferase, and hexokinase activities as well as GLUT-2 and GLUT-4 levels. The data from this study suggest that the aqueous extract of C. orbicularis leaf may be beneficial in the management of diabetic mellitus and its secondary effects.

金龟甲是一种药用植物，存在于西非尼日利亚伊塞基里语地区。它通常用于糖尿病管理。本研究探讨了轮匝肌水性叶提取物对链脲佐菌素诱导的糖尿病大鼠模型的改善活性。腹膜内给予新鲜制备的链脲佐菌素（40mg/kg体重[BW]）以诱发糖尿病。三个糖尿病组分别服用11.076、22.134 和 44.268 mg/kg BW 的轮匝肌水性叶提取物；一组服用二甲双胍（44.28 mg/kg BW），另外两组为糖尿病对照和正常对照。实验持续28天，随后记录空腹血糖水平和体重变化。此外，还使用标准程序分析了糖原水平、抗氧化酶、己糖激酶和葡萄糖 6 磷酸酶活性、丙二醛 (MDA) 以及葡萄糖转运蛋白 2 和 4 水平。糖尿病大鼠服用轮匝肌叶水提取物后，空腹血糖和 MDA 水平以及葡萄糖 6 磷酸酶活性显着降低（p < 0.05）。此外，对糖尿病大鼠施用轮匝肌叶水提取物显示肝糖原水平、超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、还原型谷胱甘肽、谷胱甘肽转移酶和己糖激酶活性以及 GLUT-2 和 GLUT- 显着增加。 4 个级别。这项研究的数据表明，轮匝肌叶的水提取物可能有益于治疗糖尿病及其副作用。