Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation. The absolute configurations of compounds 1 and 2 were established using TDDFT-ECD calculation of the selected isomers. Bisnaecarpamine A exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC₅₀ value of 28.8 µM.

Graphic abstract

中文翻译：

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Tabernaemontana macrocarpa Jack的两种新的双吲哚生物碱

从塔贝奈蒙塔那克（Tabernaemontana macrocarpa Jack）的树皮中分离出两个新的双吲哚生物碱，比那卡巴胺A（1）和B（2），它们具有vobasine-sarpagine型骨架。通过广泛的光谱学方法和化学相关性阐明了它们的结构。使用TDDFT-ECD计算所选异构体，可以确定化合物1和2的绝对构型。Bisnaecarpamine A对恶性疟原虫3D7菌株表现出有效的抗疟疾活性，IC ₅₀值为28.8 µM。

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