A method using ion chromatography coupled to high-resolution Orbitrap mass spectrometry was developed to quantify highly-polar organic compounds in aqueous filter extracts of atmospheric particles. In total, 43 compounds, including short-chain carboxylic acids, terpene-derived acids, organosulfates, and inorganic anions were separated within 33 min by a KOH gradient. Ionization by electrospray was maximized by adding 100 µL min⁻¹ isopropanol as post-column solvent and optimizing the ion source settings. Detection limits (S/N ≥ 3) were in the range of 0.075–25 μg L⁻¹ and better than previously reported for 22 compounds. Recoveries of extraction typically range from 85 to 117%. The developed method was applied to three ambient samples, including two arctic flight samples, and one sample from Melpitz, a continental backround research site. A total of 32 different compounds were identified for all samples. From the arctic flight samples, organic tracers could be quantified for the first time with concentrations ranging from 0.1 to 17.8 ng m⁻³. Due to the minimal sample preparation, the beneficial figures of merit, and the broad range of accessible compounds, including very polar ones, the new method offers advantages over existing ones and enables a detailed analysis of organic marker compounds in atmospheric aerosol particles.

中文翻译：

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使用离子色谱法 Orbitrap 质谱法测定大气气溶胶颗粒中超痕量水平的高极性化合物

开发了一种使用离子色谱法与高分辨率 Orbitrap 质谱联用的方法，以量化大气颗粒物的水性过滤器提取物中的高极性有机化合物。总共 43 种化合物，包括短链羧酸、萜烯衍生酸、有机硫酸盐和无机阴离子，在 33 分钟内通过 KOH 梯度分离。通过添加 100 µL min ^-1异丙醇作为柱后溶剂并优化离子源设置，使电喷雾电离最大化。检测限 (S/N ≥ 3) 范围为 0.075–25 μg L ^-1并且比之前报道的 22 种化合物更好。萃取回收率通常在 85% 到 117% 之间。开发的方法应用于三个环境样本，包括两个北极飞行样本和一个来自大陆背景研究站点梅尔皮茨的样本。所有样品共鉴定出 32 种不同的化合物。从北极飞行样本中，有机示踪剂首次被量化，其浓度范围为 0.1 至 17.8 ng m ^-3。由于最少的样品制备、有益的品质因数和范围广泛的可获取化合物，包括极极性的化合物，新方法比现有方法具有优势，并且能够对大气气溶胶颗粒中的有机标记化合物进行详细分析。