The Santhal tribe in Assam, India use the roots of Asparagus racemosus (Asparagaceae) as a deworming remedy. The study aimed to investigate the anthelmintic credentials of this plant, using two representative groups of helminth parasites. The in vitro testing was conducted against Hymenolepis diminuta (cestode) and Syphacia obvelata (nematode). Parasites were exposed to 10, 20 and 30 mg/ml concentrations of plant extract, and efficacy was adjudged on the basis of parasites paralysis and mortality. In vivo efficacy was examined using H. diminuta-rat and S. obvelata-mice models where animals were administered 125, 250 and 500 mg/kg doses of extract. In vitro assay, against H. diminuta revealed that at 30 mg/ml concentration the extract showed almost a comparable efficacy with that of reference drug praziquantel (PZQ) (1 mg/ml). The in vitro efficacy of extract against S. obvelata was however lower than H. diminuta. In vivo studies against H. diminuta at 500 mg/kg revealed 53.88 and 24 % reduction in eggs per gram (EPG) and worm counts respectively. Against S. obvelata the extract showed 26.61 and 30.93 % reduction for the same. The findings of this study present suggest that the roots of A. racemosus are effective against intestinal helminthic infections and justifies its use as an anthelmintic in the traditional medicine of the Santhals.

中文翻译：

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芦笋芦笋根的驱虫潜力的研究。（天门冬科）

印度阿萨姆邦的Santhal部落使用芦笋芦笋（Asparagaceae）的根作为驱虫药。该研究旨在利用两个代表性的蠕虫寄生虫来调查该植物的驱虫能力。进行了体外试验，该试验针对的是Hymenolepis diminuta（甲虫）和Syphacia obvelata（线虫）。将寄生虫暴露于浓度为10、20和30 mg / ml的植物提取物，并根据寄生虫的瘫痪和死亡率来判断疗效。使用H. diminuta-rat和S. obvelata-小鼠模型检查体内功效，其中给动物施用125、250和500 mg / kg剂量的提取物。在体外，针对小型嗜血杆菌（H. diminuta）的分析显示，在30 mg / ml的浓度下，提取物的功效几乎与参考药物吡喹酮（PZQ）（1 mg / ml）相当。然而，提取物对盾形葡萄球菌的体外功效低于丁香链球菌。对500 mg / kg的微小链球菌的体内研究表明，每克鸡蛋（EPG）和蠕虫计数分别降低了53.88和24％。提取物对扁叶葡萄球菌的去除率分别为26.61％和30.93％。本研究的发现表明，沙曲霉的根可有效抵抗肠道蠕虫感染，并证明其可作为桑塔斯的传统药物中的驱虫药使用。