Propolis (bee glue) is a sticky material collected by bees from plant resins, it has been proven to possess numerous beneficial pharmacological properties: antibacterial, antiviral, antioxidant, antiinflammatory, immunostimulating, hepatoprotective, cytotoxic, etc. Nowadays, propolis is a popular remedy all over the world, and is available in either pure form or combined with other natural products in over-the-counter preparations, cosmetics, and as a constituent of health foods. The interest in propolis containing commercial products is steadily growing. The extraction is a key step in making use of the bioactive constituents of propolis. The present review summarizes and discusses the available data about classical and modern methods of extraction of propolis with potential large-scale application. The published data concerning maceration, Soxhlet, ultrasound-assisted and microwave-assisted extraction, supercritical CO₂ extraction, high-pressure methods, and the application of different solvents are discussed. Concerning the solvents, water – ethanol mixtures remain among the most effective, oil and natural deep eutectic solvents (NADES) have demonstrated promising potential. From the extraction processes, ultrasound-assisted extraction seems to be the optimal method, taking into account extraction time and extraction yield. Of course, more studies are necessary to find the best way to extract bioactive compounds from different types of propolis, based on chemometric optimization approaches, especially with respect to large-scale application.

蜂胶（蜂胶）是蜜蜂从植物树脂中收集的粘性物质，已被证明具有许多有益的药理特性：抗菌、抗病毒、抗氧化、抗炎、免疫刺激、保肝、细胞毒性等。 如今，蜂胶是一种流行的药物在世界各地，可以以纯净形式或与其他天然产品结合用于非处方制剂、化妆品和作为健康食品的成分。对含有商业产品的蜂胶的兴趣正在稳步增长。提取是利用蜂胶生物活性成分的关键步骤。本综述总结并讨论了具有潜在大规模应用潜力的蜂胶提取方法的经典和现代可用数据。已公布的浸渍数据，_{2 讨论了}萃取、高压方法和不同溶剂的应用。关于溶剂，水 - 乙醇混合物仍然是最有效的，石油和天然低共熔溶剂 (NADES) 已显示出有希望的潜力。从提取过程来看，考虑到提取时间和提取率，超声辅助提取似乎是最佳方法。当然，需要更多的研究来找到基于化学计量学优化方法从不同类型蜂胶中提取生物活性化合物的最佳方法，尤其是在大规模应用方面。