Deep brain stimulation is a treatment option for patients with refractory obsessive-compulsive disorder. A new generation of stimulators hold promise for closed loop stimulation, with adaptive stimulation in response to biological signals Here we aimed to discover a suitable biomarker in the ventral striatum in patients with obsessive compulsive disorder using local field potentials. We induced obsessions and compulsions and trained a deep learning model on the recorded time series. Average classification sensitivities were 47% for obsessions and 66% for compulsions for patient specific models at 25% chance level. Sensitivity for obsessions reached over 90% in one patient, whereas performance was near chance level when the model was trained across patients. Optimal sensitivity for obsessions and compulsions was obtained at different recording sites. This study shows that closed loop stimulation is a viable option for OCD, but that intracranial biomarkers for obsessive-compulsive disorder are patient and not disorder specific.

中文翻译：

---

腹侧纹状体具有痴迷和强迫症的患者特定的颅内神经信号

对于难治性强迫症患者，深部脑刺激是一种治疗选择。新一代刺激器有望对闭环刺激产生响应，并能响应生物信号进行适应性刺激。在这里，我们旨在利用局部场电位在强迫症患者的腹侧纹状体中发现合适的生物标志物。我们诱发了强迫症和强迫症，并在记录的时间序列上训练了深度学习模型。在25％的机会水平下，针对特定患者模型，对于痴迷的平均分类敏感度为47％，对于强迫症的平均分类敏感度为66％。一名患者对强迫症的敏感度达到90％以上，而跨患者训练模型时的表现接近偶然水平。在不同的录音地点获得了对强迫症和强迫症的最佳敏感性。这项研究表明，闭环刺激是强迫症的可行选择，但强迫症的颅内生物标志物是患者而非特定疾病。