The solubility of drugs in supercritical carbon dioxide (ScCO₂) is crucial information for crystal engineering designs and pharmaceutical applications. A semi-flow apparatus was used to measure the solubility of gliclazide and captopril in ScCO₂ at 308.2 K, 318.2 K, and 328.2 K within the pressure range of 10.0–18.6 MPa. The newly measured solubility data were correlated and confirmed to be self-consistency with four semi-empirical correlation models: Chrastil, Méndez-Santiago & Teja (MST), Bartle, and Kumar & Johnston (K-J). The newly measured data were then used to evaluate the accuracy of three approaches based on the Peng-Robinson equation of state (PR EOS). PR EOS combining with the Wilson model through the Wong-Sandler mixing rule with two adjustable parameters shown excellent fit with experimental data, while PR EOS combining with the COSMO-SAC model through the MHV1 mixing rule provided reasonable solubility prediction without adjustable parameters.

药物在超临界二氧化碳（ScCO ₂）中的溶解度对于晶体工程设计和药物应用至关重要。使用半流动装置测量格列齐特和卡托普利在ScCO _2中的溶解度在10.0-18.6 MPa的压力范围内，最大压力为308.2 K，318.2 K和328.2K。将新测得的溶解度数据与四个半经验相关模型进行关联，并确认它们是自洽的：Chrastil，Méndez-Santiago＆Teja（MST），Bartle和Kumar＆Johnston（KJ）。然后，将新测量的数据用于基于Peng-Robinson状态方程（PR EOS）的三种方法的准确性评估。PR EOS通过具有两个可调参数的Wong-Sandler混合规则与Wilson模型结合，显示出与实验数据的极佳拟合，而PR EOS通过MHV1混合规则与COSMO-SAC模型结合，提供了无可调参数的合理溶解度预测。