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Topological defects produce kinks in biopolymer filament bundles [Biophysics and Computational Biology]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.412 ) Pub Date : 2021-04-13 , DOI: 10.1073/pnas.2024362118
Valentin M. Slepukhin, Maximilian J. Grill, Qingda Hu, Elliot L. Botvinick, Wolfgang A. Wall, Alex J. Levine

Bundles of stiff filaments are ubiquitous in the living world, found both in the cytoskeleton and in the extracellular medium. These bundles are typically held together by smaller cross-linking molecules. We demonstrate, analytically, numerically, and experimentally, that such bundles can be kinked, that is, have localized regions of high curvature that are long-lived metastable states. We propose three possible mechanisms of kink stabilization: a difference in trapped length of the filament segments between two cross-links, a dislocation where the endpoint of a filament occurs within the bundle, and the braiding of the filaments in the bundle. At a high concentration of cross-links, the last two effects lead to the topologically protected kinked states. Finally, we explore, numerically and analytically, the transition of the metastable kinked state to the stable straight bundle.



中文翻译:

拓扑缺陷会在生物聚合物长丝束中产生扭结[生物物理学和计算生物学]

刚性丝束在生活世界中无处不在,在细胞骨架和细胞外培养基中均可发现。这些束通常通过较小的交联分子保持在一起。我们通过分析,数值和实验证明,这些束可以扭结,即具有高曲率的局部区域,该区域是长寿命的亚稳态。我们提出了三种可能的扭结稳定机制:两个交联之间的丝段截留长度的差异,在丝束内出现丝的端点的错位以及束中丝的编织。在高浓度的交联下,后两种作用导致拓扑受保护的扭结态。最后,我们在数值和分析上进行探索,

更新日期:2021-04-06
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