Heliyon ( IF 3.4 ) Pub Date : 2021-04-05 , DOI: 10.1016/j.heliyon.2021.e06706 Abdullah Alshukry 1 , Mohammad Bu Abbas 1 , Yaseen Ali 1 , Barrak Alahmad 2 , Abdullah A Al-Shammari 3, 4 , Ghadeer Alhamar 3, 5 , Mohammad Abu-Farha 3 , Jehad AbuBaker 3 , Sriraman Devarajan 3 , Ali A Dashti 6 , Fahd Al-Mulla 3 , Hamad Ali 3, 6
Background
COVID-19 has a highly variable clinical presentation, ranging from asymptomatic to severe respiratory symptoms and death. Diabetes seems to be one of the main comorbidities contributing to a worse COVID-19 outcome.
Objective
In here we analyze the clinical characteristics and outcomes of diabetic COVID-19 patients Kuwait.
Methods
In this single-center, retrospective study of 417 consecutive COVID-19 patients, we analyze and compare disease severity, outcome, associated complications, and clinical laboratory findings between diabetic and non-diabetic COVID-19 patients.
Results
COVID-19 patients with diabetes had more ICU admission than non-diabetic COVID-19 patients (20.1% vs. 16.8%, p < 0.001). Diabetic COVID-19 patients also recorded higher mortality in comparison to non-diabetic COVID-19 patients (16.7% vs. 12.1%, p < 0.001). Diabetic COVID-19 patients had significantly higher prevalence of comorbidities, such as hypertension. Laboratory investigations also highlighted notably higher levels of C-reactive protein in diabetic COVID019 patients and lower estimated glomerular filtration rate. They also showed a higher incidence of complications. logistic regression analysis showed that every 1 mmol/L increase in fasting blood glucose in COVID-19 patients is associated with 1.52 (95% CI: 1.34–1.72, p < 0.001) times the odds of dying from COVID-19.
Conclusion
Diabetes is a major contributor to worsening outcomes in COVID-19 patients. Understanding the pathophysiology underlining these findings could provide insight into better management and improved outcome of such cases.
中文翻译:
科威特 COVID-19 糖尿病患者的临床特征和结果
背景
COVID-19 的临床表现差异很大,从无症状到严重呼吸道症状甚至死亡。糖尿病似乎是导致 COVID-19 结局恶化的主要合并症之一。
客观的
在此,我们分析了科威特糖尿病 COVID-19 患者的临床特征和结果。
方法
在这项对 417 名连续 COVID-19 患者进行的单中心回顾性研究中,我们分析并比较了糖尿病和非糖尿病 COVID-19 患者的疾病严重程度、结果、相关并发症和临床实验室检查结果。
结果
患有糖尿病的 COVID-19 患者比非糖尿病 COVID-19 患者入住 ICU 的比例更高(20.1% vs. 16.8%,p < 0.001)。与非糖尿病 COVID-19 患者相比,糖尿病 COVID-19 患者的死亡率也更高(16.7% vs. 12.1%,p < 0.001)。糖尿病 COVID-19 患者的高血压等合并症患病率明显较高。实验室调查还强调,糖尿病患者的 C 反应蛋白水平明显较高,估计肾小球滤过率较低。他们还表现出较高的并发症发生率。Logistic 回归分析显示,COVID-19 患者空腹血糖每增加 1 mmol/L,死于 COVID-19 的几率就会增加 1.52(95% CI:1.34–1.72,p < 0.001)倍。
结论
糖尿病是导致 COVID-19 患者预后恶化的一个主要原因。了解这些发现背后的病理生理学可以帮助我们深入了解此类病例的更好管理和改善结果。