Antidepressants are a class of compounds widely used in clinical settings for the treatment of several diseases. In the last years there has been a considerable increase in their consumption, representing an important public health issue in several countries. Because they are substances with narrow therapeutic windows, and since they are capable of interacting with other classes of compounds, monitoring of these compounds is of relevance, minimizing the risk of medical interactions as well as side and toxic effects. In addition, understanding the extent of their use, their detection through routine toxicology tests and development of new methods for detection and monitoring is of extreme importance concerning public health, patient well-being, and implications in clinical and forensic situations. The main objective of this work is to perform a critical review on the biological samples used in the detection and quantification of antidepressants with special focus on the techniques for sample preparation.

中文翻译：

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样品预处理技术中目前用于确定生物样品中抗抑郁药的生物分析方法的综述

抗抑郁药是一类在临床上广泛用于治疗多种疾病的化合物。在过去的几年中，它们的消费量大量增加，这在一些国家代表了一个重要的公共卫生问题。由于它们是具有狭窄治疗窗口的物质，并且由于它们能够与其他类型的化合物相互作用，因此对这些化合物的监测具有相关性，可最大程度地减少医学相互作用以及副作用和毒性作用的风险。此外，了解它们的使用范围，通过常规毒理学检测进行检测以及开发新的检测和监测方法对于公共卫生，患者的健康状况以及在临床和法医鉴定中的意义至关重要。