P(MMA-co-HPMA)-b-POEGMA copolymers: synthesis, micelle formation in aqueous media and drug encapsulation,Polymer International

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P(MMA-co-HPMA)-b-POEGMA copolymers: synthesis, micelle formation in aqueous media and drug encapsulation
Polymer International ( IF 2.9 ) Pub Date : 2021-04-05 , DOI: 10.1002/pi.6229
Dimitrios Selianitis ₁ , Stergios Pispas ₁

Affiliation

We report the synthesis and the micellar self-assembly in aqueous media of novel amphiphilic block copolymers. The copolymers consist of a poly[(methyl methacrylate)-co-(hydroxypropyl methacrylate)] statistical copolymer block and a poly[oligo(ethylene glycol) methyl ether methacrylate] block, and were synthesized by reversible addition–fragmentation chain transfer polymerization. The amphiphilic P(MMA-co-HPMA)-b-POEGMA block copolymers contain monomers of differing polarity and in varying ratios. Furthermore, HPMA segments are chosen in order to enhance hydrogen bonding interactions within the core of spherical micelles formed by the copolymers in aqueous media, as evidenced by light scattering and fluorescence spectroscopy studies. The amphiphilic copolymers are able to encapsulate the hydrophobic drugs curcumin and indomethacin as found using light scattering and spectroscopic methods. © 2021 Society of Industrial Chemistry.

中文翻译：

P(MMA-co-HPMA)-b-POEGMA 共聚物：合成、水性介质中的胶束形成和药物封装

我们报告了新型两亲性嵌段共聚物在水性介质中的合成和胶束自组装。该共聚物由聚[(甲基丙烯酸甲酯) -co- (甲基丙烯酸羟丙酯)]统计共聚物嵌段和聚[低聚(乙二醇)甲基醚甲基丙烯酸酯]嵌段组成，通过可逆加成-断裂链转移聚合反应合成。两亲性 P(MMA- co -HPMA)- b-POEGMA 嵌段共聚物包含不同极性和不同比例的单体。此外，选择 HPMA 链段是为了增强由共聚物在水性介质中形成的球形胶束核心内的氢键相互作用，光散射和荧光光谱研究证明了这一点。如使用光散射和光谱方法发现的，两亲共聚物能够封装疏水性药物姜黄素和消炎痛。© 2021 工业化学学会。

更新日期：2021-04-05

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