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Structural determination of four manufacturing impurities of D&C Red No. 33
Magnetic Resonance in Chemistry ( IF 1.9 ) Pub Date : 2021-04-05 , DOI: 10.1002/mrc.5160 Eugene P Mazzola 1 , Adrian Weisz 2 , Douglas P Ridge 3 , Sarah E Donnelly 4 , Hanwen Zhang 1 , Raquel M Gonzalez 5 , Luke K Ackerman 4 , Kristen L Reese 4 , Clark D Ridge 4
Magnetic Resonance in Chemistry ( IF 1.9 ) Pub Date : 2021-04-05 , DOI: 10.1002/mrc.5160 Eugene P Mazzola 1 , Adrian Weisz 2 , Douglas P Ridge 3 , Sarah E Donnelly 4 , Hanwen Zhang 1 , Raquel M Gonzalez 5 , Luke K Ackerman 4 , Kristen L Reese 4 , Clark D Ridge 4
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Four manufacturing impurities of D&C Red No. 33 isolated by counter-current chromatography were analyzed by NMR and ESI mass spectrometry. Three of these impurities were reported previously with minimal details of structural determination. All four are structurally related to the main component of the dye. The fourth exhibited an unusual discrepancy between the NMR structure and its chemical formula suggested by ESI-MS results. Structural determination and assignment of the main component and four impurities are discussed as well as resolution of the discrepancy between the NMR and ESI-MS results of the fourth impurity.
中文翻译：
D&C红33号四种制造杂质的结构测定
通过逆流色谱法分离的 D&C Red No. 33 的四种制造杂质通过 NMR 和 ESI 质谱法进行分析。其中三种杂质先前已报告，但结构测定的细节很少。所有四种在结构上都与染料的主要成分有关。第四个展示了 NMR 结构与其 ESI-MS 结果表明的化学式之间的异常差异。讨论了主要成分和四种杂质的结构测定和归属，以及第四种杂质的 NMR 和 ESI-MS 结果之间差异的解决方法。
更新日期：2021-04-05
中文翻译：
D&C红33号四种制造杂质的结构测定
通过逆流色谱法分离的 D&C Red No. 33 的四种制造杂质通过 NMR 和 ESI 质谱法进行分析。其中三种杂质先前已报告，但结构测定的细节很少。所有四种在结构上都与染料的主要成分有关。第四个展示了 NMR 结构与其 ESI-MS 结果表明的化学式之间的异常差异。讨论了主要成分和四种杂质的结构测定和归属，以及第四种杂质的 NMR 和 ESI-MS 结果之间差异的解决方法。
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