Abstract

Residual cognitive symptoms are associated with reduced daily life functioning, quality of life and represent a risk factor for relapse of major depressive disorder (MDD). There are few studies targeting self-perceived residual cognitive symptoms after MDD. The current open pilot study examines clinical outcomes and feasibility of a novel internet-delivered cognitive enhancement treatment for mood disorders specifically tailored to target self-perceived residual cognitive symptoms after MDD. A total of 43 adults with self-perceived residual cognitive symptoms after MDD were included. Participants were assessed pre- and post-treatment and at 6-month follow-up. The intervention consists of 10 modules that includes psychoeducation, cognitive strategies, and attention training, coupled with weekly therapist guidance. Results showed a significant reduction from pre- to post-treatment in self-perceived residual cognitive symptoms (d = 0.98) and rumination (d = 0.63). Results remained significant at the 6-month follow-up (d = 1.06; d = 0.86). Reliable change in self-perceived residual cognitive symptoms were obtained in 60% of the participants from pre- to post-treatment. Completion rates (86%) and treatment satisfaction (97%) were high. This open pilot study supports that targeting self-perceived residual cognitive symptoms after MDD through internet-delivered cognitive enhancement therapy for mood disorders may be feasible and provide stable reductions in self-perceived residual cognitive symptoms and rumination.

摘要

残留的认知症状与日常生活功能、生活质量降低有关，是重度抑郁症 (MDD) 复发的危险因素。很少有针对 MDD 后自我感知的残余认知症状的研究。目前的开放试点研究检查了一种新型的互联网提供的认知增强治疗情绪障碍的临床结果和可行性，该治疗专门针对 MDD 后自我感知的残余认知症状而定制。共纳入 43 名在 MDD 后具有自我认知残留认知症状的成年人。参与者在治疗前和治疗后以及 6 个月的随访中进行了评估。该干预由 10 个模块组成，包括心理教育、认知策略和注意力训练，以及每周的治疗师指导。d  = 0.98）和反刍（d  = 0.63）。在 6 个月的随访中，结果仍然显着（d  = 1.06；d  = 0.86）。从治疗前到治疗后，60% 的参与者获得了自我感知的残余认知症状的可靠变化。完成率 (86%) 和治疗满意度 (97%) 都很高。这项开放的试点研究支持通过互联网提供的情绪障碍认知增强疗法来针对 MDD 后自我感知的残余认知症状可能是可行的，并且可以稳定地减少自我感知的残余认知症状和反刍。