Strategies for discovering resistance-breaking, safe and sustainable commercial herbicides with novel modes of action and chemotypes,Pest Management Science

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Strategies for discovering resistance-breaking, safe and sustainable commercial herbicides with novel modes of action and chemotypes
Pest Management Science ( IF 3.8 ) Pub Date : 2021-04-04 , DOI: 10.1002/ps.6397
Shuji Hachisu ₁

Affiliation

Farmers need to manage weeds to grow and harvest crops that are essential to our food and energy supply, and herbicides are the most important tool in the farmers' armory to combat weeds. There is now a crisis in agriculture that has been brought about by herbicides being rendered ineffective by resistant weeds or withdrawn from the market due to safety concerns. Efficacious herbicides with novel modes of action (MoAs) and chemotypes are urgently needed to control resistant weeds and satisfy public and regulators' stringent requirements for safe and sustainable products. This article explores the main strategies being deployed by academic and industrial institutions to discover the next generation of commercial herbicides: phenotypic and in vitro target based approaches. There are early signs that much needed innovation and herbicidal products with novel MoAs are on the horizon from start-ups and established agrochemical companies. © 2021 Society of Chemical Industry. © 2021 Society of Chemical Industry.

中文翻译：

发现具有新作用模式和化学型的抗性破坏、安全和可持续的商业除草剂的策略

农民需要管理杂草来种植和收获对我们的食物和能源供应至关重要的作物，而除草剂是农民军械库中对抗杂草的最重要工具。现在，由于抗性杂草使除草剂失效或出于安全考虑从市场上撤出，给农业带来了危机。迫切需要具有新型作用方式 (MoAs) 和化学型的有效除草剂来控制抗性杂草并满足公众和监管机构对安全和可持续产品的严格要求。本文探讨了学术和工业机构为发现下一代商业除草剂而部署的主要策略：表型和体外基于目标的方法。有早期迹象表明，初创企业和成熟的农化公司急需的创新和具有新型 MoA 的除草产品即将出现。© 2021 化学工业协会。© 2021 化学工业协会。

更新日期：2021-06-10

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