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Fluorescent boron carbide quantum dots synthesized with a low-temperature solvothermal approach for boron neutron capture therapy
Physica E: Low-dimensional Systems and Nanostructures ( IF 2.9 ) Pub Date : 2021-04-01 , DOI: 10.1016/j.physe.2021.114766
Paviter Singh , Manjot Kaur , Kulwinder Singh , Ramovatar Meena , Manjeet Kumar , Ju-Hyung Yun , Anup Thakur , Fumiko Nakagawa , Minoru Suzuki , Hiroyuki Nakamura , Akshay Kumar

A facile relatively lower temperature solvothermal approach has been used to synthesize boron carbide quantum dots (~7 nm in size). The detailed structural analysis emphasizes the presence of defect states due to which B4C yielded 1.5 times more fluorescence intensity in tumor cells than normal cell lines. Detailed cytotoxicity and boron neutron capture therapy (BNCT) studies have been analyzed. The synthesized material has the potential to stand with traditional clinically studied boron agents (L-BPA) in BNCT. Therefore, the synthesized B4C quantum dots can act as a potential candidate for detector as well as treatment for tumor cells.



中文翻译:

低温溶剂热法合成的碳化硼荧光量子点用于硼中子俘获治疗

已经使用一种相对较低温度的溶剂热方法来合成碳化硼量子点(尺寸约为7 nm)。详细的结构分析强调了缺陷状态的存在,由于该缺陷状态,B 4 C在肿瘤细胞中产生的荧光强度是正常细胞系的1.5倍。分析了详细的细胞毒性和硼中子捕获疗法(BNCT)研究。合成的材料具有与BNCT中传统的临床研究硼剂(L-BPA)保持一致的潜力。因此,合成的B 4 C量子点可以充当检测器以及肿瘤细胞治疗的潜在候选者。

更新日期:2021-04-09
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